Publications

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Organoids
ALL

The landscape of drug sensitivity and resistance in sarcoma

Al Shihabi A, Tebon PJ, Nguyen HTL, Chantharasamee J, Sartini S, Davarifar A, Jensen A, Diaz-Infante M, Cox H, Gonzalez AE, Norris S, Sperry J, Nakashima J, Tavanaie N, Winata H, Fitz-Gibbon ST, Yamaguchi TN, Jeong JH, Dry S, Singh A, Chmielowski B, Crompton JG, Kalbasi A, Eilber FC, Hornicek F, Bernthal N, Nelson SD, Boutros PC, Federman N, Yanagawa J, Soragni A
(
2024
)
Cell Stem Cell
|
Preprint
Protein Aggregation
ALL

Mutant p53 Misfolding and Aggregation Precedes Transformation into High-Grade Serous Ovarian Carcinoma

Sartini S, Omholt L, Moatamed N, Soragni A
(
2024
)
bioRxiv
|
Preprint

Work featured on:

Opinion Piece
ALL

Roadmap for the next generation of Children’s Oncology Group rhabdomyosarcoma trials

Metts JL, Aye JM, Crane JN, Oberoi S, Balis FM, Bhatia S, Bona K, Carleton B, Dasgupta R, Dela Cruz F, Greenzang KA, Kaufman J, Linardic CM, Parsons SK, Robertson-Tessi M, Rudzinski ER, Soragni A, Stewart E, Weigel BJ, Wolden SL, Weiss AR, Venkatramani R, Heske CM
(
2024
)
Cancer
|
Preprint

Work featured on:

Organoids
ALL

A platform for rapid patient-derived cutaneous neurofibroma organoid establishment and screening

Nguyen HTL, Kohl E, Bade J, Eng SE, Tosevska A, Al Shihabi A, Tebon P, Hong JJ, Dry S, Boutros PC, Panossian A, Gosline SJC, Soragni A
(
2024
)
Cell Reports Methods
|
Preprint
Protein Aggregation
ALL

Membrane damage by MBP-1 is mediated by pore formation and amplified by mtDNA

Gigon L, Müller P, Haenni B, Iacovache I, Barbo M, Gosheva G, Yousefi S, Soragni A, von Ballmoos C, Zuber B, Simon H-U
(
2024
)
Cell Reports
|
Preprint

Work featured on:

Organoids
ALL

Drug screening at single-organoid resolution via bioprinting and interferometry

Tebon PJ, Wang B, Markowitz AL, Davarifar A, Tsai BL, Krawczuk P, Gonzalez AE, Sartini S, Murray GF, Nguyen HTL, Tavanaie N, Nguyen TL, Boutros PC, Teitell MA, Soragni A
(
2023
)
Nature Communications
|
Preprint
Organoids
ALL

Organoids

Zhao Z, Chen X, Dowbaj AM, Sljukic A, Bratlie K, Lin L, Fong ELS, Balachander GM, Chen Z, Soragni A*, Huch M*, Zeng YA*, Wang Q*, Yu H*. *co-corresponding
(
2022
)
Nature Reviews Methods Primers
|
Preprint

Work featured on:

Organoids
ALL

Personalized chordoma organoids for drug discovery studies

Al Shihabi A, Davarifar A, Nguyen HTL, Tavanaie N, Nelson SD, Yanagawa J, Federman N, Bernthal N, Hornicek F, Soragni A
(
2022
)
Science Advances
|
Preprint
Organoids
ALL

Cervical organoids go viral

Zhao Z, Chen X, Dowbaj AM, Sljukic A, Bratlie K, Lin L, Fong ELS, Balachander GM, Chen Z, Soragni A, Huch M, Zeng YA, Wang Q, Yu H
(
2021
)
Cell Stem Cell
|
Preprint

Work featured on:

Organoids
ALL

Patient-derived tumor organoid rings for histologic characterization and high-throughput screening

Nguyen HTL, Soragni A
(
2020
)
STAR Protocols
|
Preprint

Work featured on:

Protein Aggregation
ALL

p53 reactivation: Chasing the “untargetable” to circumvent resistance

Soragni A
(
2020
)
Overcoming Ovarian Cancer Chemoresistance
|
Preprint

Work featured on:

Opinion Piece
ALL

Of Scientists and tweets

Soragni A, Maitra A
(
2019
)
Nature Reviews Cancer
|
Preprint

Work featured on:

Organoids
ALL

A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids

Phan N, Hong JJ,Tofig B, Mapua M, Elashoff D, Moatamed NA, Huang J, Memarzadeh S, Damoiseaux R, Soragni A
(
2019
)
Communications Biology
|
Preprint

Work featured on:

Opinion Piece
ALL

Journal clubs in the time of preprints

Avasthi P, Soragni A, Bembenek JN
(
2018
)
eLife
|
Preprint

Work featured on:

Organoids
ALL
Protein Aggregation
ALL

A designed inhibitor of p53 aggregation rescues p53 tumor suppression in ovarian carcinomas

Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS
(
2016
)
Cancer Cell
|
Preprint

Work featured on:

Protein Aggregation
ALL

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation

Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU
(
2015
)
Molecular Cell
|
Preprint

Work featured on:

Protein Aggregation
ALL

Superresolution imaging of amyloid fibrils with binding-activated probes

Ries J, Udayar V, Soragni A, Hornemann S, Nilsson KP, Riek R, Hock C, Ewers H, Aguzzi AA, Rajendran L
(
2013
)
ACS Chemical Neuroscience
|
Preprint

Work featured on:

Protein Aggregation
ALL

On-surface aggregation of α-synuclein at nanomolar concentrations results in two distinct growth mechanisms

Rabe M, Soragni A, Reynolds NP, Verdes D, Liverani E, Riek R, Seeger S
(
2013
)
ACS Chemical Neuroscience
|
Preprint

Work featured on:

Protein Aggregation
ALL

Mechanism of membrane interaction and disruption by α-synuclein

Reynolds NP, Soragni A, Rabe M, Verdes D, Liverani E, Handschin S, Riek R, Seeger S
(
2011
)
Journal of the American Chemical Society
|
Preprint

Work featured on:

Protein Aggregation
ALL

The amyloid-Congo red interface at atomic resolution

Schütz AK, Soragni A, Hornemann S, Aguzzi A, Ernst M, Böckmann A, Meier BH
(
2011
)
Angewandte Chemie
|
Preprint

Work featured on:

Protein Aggregation
ALL

In vivo demonstration that α-synuclein oligomers are toxic

Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R
(
2011
)
PNAS
|
Preprint

Work featured on:

Protein Aggregation
ALL

Structural similarity between the prion domain of HET-s and a homologue can explain amyloid cross-seeding in spite of limited sequence identity

Wasmer C, Zimmer A, Sabaté R, Soragni A, Saupe SJ, Ritter C, Meier BH
(
2010
)
Journal of Molecular Biology
|
Preprint

Work featured on:

Protein Aggregation
ALL

The mechanism of prion inhibition by HET-S

Greenwald J, Buhtz C, Ritter C, Kwiatkowski W, Choe S, Maddelein ML, Ness F, Cescau S, Soragni A, Leitz D, Saupe SJ, Riek R
(
2010
)
Molecular Cell
|
Preprint

Work featured on:

Protein Aggregation
ALL

A combined solid-state NMR and MD characterization of the stability and dynamics of the HET-s(218-289) prion in its amyloid conformation

Lange A, Gattin Z, Van Melckebeke H, Wasmer C, Soragni A, van Gunsteren WF, Meier BH
(
2009
)
ChemBioChem
|
Preprint

Work featured on:

Protein Aggregation
ALL

Structural characterization of binding of Cu(II) to tau protein

Soragni A, Zambelli B, Mukrasch MD, Biernat J, Jeganathan S, Griesinger C, Ciurli S, Mandelkow E, Zweckstetter M
(
2008
)
Biochemistry
|
Preprint

Work featured on:

Protein Aggregation
ALL

Infectious and noninfectious amyloids of the HET-s(218-289) prion have different NMR spectra

Wasmer C, Soragni A, Sabaté R, Lange A, Riek R, Meier BH
(
2008
)
Angewandte Chemie
|
Preprint

Work featured on:

No items found.

Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins

Aachmann FL, Fomenko DE, Soragni A, Gladyshev VN, Dikiy A
(
2007
)
Journal of Biological Chemistry
|
Preprint

Work featured on:

No items found.

In vitro analysis of protein-operator interactions of the NikR and fur metal-responsive regulators of coregulated genes in Helicobacter pylori

Delany I, Ieva R, Soragni A, Hilleringmann M, Rappuoli R, Scarlato V
(
2005
)
Journal of Bacteriology
|
Preprint

Work featured on: